CATdb: CircRNA of All Types

Comprehensive resource for exploring and analyzing circular RNAs, including both canonical and non-canonical types, across multiple species and sources

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Welcome to CATdb: A Comprehensive Database for Circular RNAs

Circular RNAs (circRNAs) are a vital class of RNA molecules that play key roles in gene expression regulation. However, researchers often need a unified platform that integrates all types of circRNAs and provides in-depth functional annotation. CATdb fulfills this need by cataloging a wide spectrum of circRNAs, extending beyond canonical exon-derived molecules to include those with back-splicing junctions outside of exon boundaries and those transcribed from intergenic regions.

To build this database, we utilized CAT, a novel detection method powered by a biological large model, to systematically analyze large-scale RNA sequencing data. Our analysis draws from the ENCODE project, the Sequence Read Archive (SRA), and our in-house datasets. This powerful approach allows for the highly sensitive and accurate identification of a vast collection of circRNAs from human, rhesus macaque, cynomolgus monkey, mouse, and rat across various sources and cell lines.

CATdb provides detailed functional annotations for each circRNA, including:

Expression Profiles: Showcasing expression levels and source specificity of circRNAs across different sources and cell types.
miRNA Interactions: Predicting potential microRNA binding sites on circRNAs, revealing their potential function as miRNA sponges.
Coding Potential: Identifying potential open reading frames (ORFs) and internal ribosome entry sites (IRES) within circRNAs, exploring their possibility of being translated into proteins or peptides
Cross-Species Conservation: Analyzing the conservation levels of circRNAs among different species, offering clues for identifying those with significant biological functions.

CATdb aims to provide the research community with a user-friendly, one-stop platform for easy Browse, searching, and visualization of circRNA data. We hope CATdb will serve as an invaluable resource for your research on circRNA biology, providing a solid foundation and a powerful starting point for your scientific discoveries.