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circRNA ID Gene Gene Type Strand (circRNA/Gene)
circRNA Type i

The back-fusion junctions (BFJs) of circRNAs from genic regions may have three possible positions relative to the nearest exon-intron boundaries of their cognate linear transcripts, giving rise to three circRNA subtypes:

(1) canonical (or completely boundary) circRNAs with both BFJs aligning to exon-intron boundaries;

(2) half interior (or half boundary) circRNAs with one, but not both, of the BFJs aligning to exon-intron boundaries;

(3) complete interior (or non-boundary) circRNAs with both junctions appearing inside of exons or introns.

Lariats are byproducts of splicing and can be regarded as variants of canonical circRNAs; for clarity, we list lariats separately here.

Intergenic circRNAs, derived from intergenic regions that often encode poorly annotated noncoding transcripts, can be considered a new distinct subtype of their own.

We collectively refer to complete interior, half interior, and intergenic circRNAs as noncanonical circRNAs (nc-circRNAs) to distinguish them from canonical circRNAs (c-circRNAs).

CircRNA Types Diagram
Position Length Species
DDX19B/20:59913163-59913163-59952375-59952375--/- DDX19B protein_coding -/- interior 20:59913163-59952375 39212.0 Crab-eating macaque
FLYWCH1/20:2858340-2858343-2842351-2842354-+/+ FLYWCH1 protein_coding +/+ interior 20:2858343-2842354 15989.0 Crab-eating macaque
intergenic/11:124263553-124263555-124264695-124264697--/. intergenic Na -/. intergenic 11:124263553-124264695 1142.0 Crab-eating macaque
CCDC47/16:59557325-59557326-59518142-59518143-+/- CCDC47 protein_coding +/- antisense 16:59557326-59518143 39183.0 Crab-eating macaque
intergenic/11:124264766-124264778-124264994-124265006--/. intergenic Na -/. intergenic 11:124264778-124265006 228.0 Crab-eating macaque
intergenic/11:124264962-124264976-124263592-124263606-+/. intergenic Na +/. intergenic 11:124264962-124263592 1370.0 Crab-eating macaque
intergenic/11:124264686-124264697-124264914-124264925--/. intergenic Na -/. intergenic 11:124264697-124264925 228.0 Crab-eating macaque
PRKD3/13:70953338-70953345-70953530-70953537--/+ PRKD3 protein_coding -/+ antisense 13:70953345-70953537 192.0 Crab-eating macaque
intergenic/11:124263934-124263954-124264164-124264184--/. intergenic Na -/. intergenic 11:124263954-124264184 230.0 Crab-eating macaque
CCDC127::intergenic/6:295768-295770-340272-340274--/- CCDC127::intergenic protein_coding -/- intergenic 6:295770-340274 44504.0 Crab-eating macaque