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circRNA ID Gene Gene Type Strand (circRNA/Gene)
circRNA Type i

The back-fusion junctions (BFJs) of circRNAs from genic regions may have three possible positions relative to the nearest exon-intron boundaries of their cognate linear transcripts, giving rise to three circRNA subtypes:

(1) canonical (or completely boundary) circRNAs with both BFJs aligning to exon-intron boundaries;

(2) half interior (or half boundary) circRNAs with one, but not both, of the BFJs aligning to exon-intron boundaries;

(3) complete interior (or non-boundary) circRNAs with both junctions appearing inside of exons or introns.

Lariats are byproducts of splicing and can be regarded as variants of canonical circRNAs; for clarity, we list lariats separately here.

Intergenic circRNAs, derived from intergenic regions that often encode poorly annotated noncoding transcripts, can be considered a new distinct subtype of their own.

We collectively refer to complete interior, half interior, and intergenic circRNAs as noncanonical circRNAs (nc-circRNAs) to distinguish them from canonical circRNAs (c-circRNAs).

CircRNA Types Diagram
Position Length Species
CAPZB/1:205147569-205147573-205163227-205163231--/+ CAPZB protein_coding -/+ antisense 1:205147573-205163231 15658.0 Crab-eating macaque
CCDC127::intergenic/6:305538-305540-351720-351722--/- CCDC127::intergenic protein_coding -/- intergenic 6:305540-351722 46182.0 Crab-eating macaque
intergenic::CCDC127/6:331616-331618-285705-285707-+/- intergenic::CCDC127 protein_coding +/- intergenic 6:331616-285705 45911.0 Crab-eating macaque
GSTM5/1:113949061-113949064-113937887-113937890-+/- GSTM5 protein_coding +/- antisense 1:113949064-113937890 11174.0 Crab-eating macaque
intergenic/11:124264222-124264229-124263994-124264001-+/. intergenic Na +/. intergenic 11:124264229-124264001 228.0 Crab-eating macaque
intergenic/11:124263928-124263933-124264842-124264847--/. intergenic Na -/. intergenic 11:124263928-124264842 914.0 Crab-eating macaque
intergenic/11:124265112-124265120-124264200-124264208-+/. intergenic Na +/. intergenic 11:124265120-124264208 912.0 Crab-eating macaque
intergenic::CCDC127/6:351720-351722-305538-305540-+/- intergenic::CCDC127 protein_coding +/- intergenic 6:351722-305540 46182.0 Crab-eating macaque
intergenic/11:124264448-124264449-124263992-124263993-+/. intergenic Na +/. intergenic 11:124264448-124263992 456.0 Crab-eating macaque
intergenic/11:124264050-124264070-124264734-124264754--/. intergenic Na -/. intergenic 11:124264053-124264737 684.0 Crab-eating macaque