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circRNA ID Gene Gene Type Strand (circRNA/Gene)
circRNA Type i

The back-fusion junctions (BFJs) of circRNAs from genic regions may have three possible positions relative to the nearest exon-intron boundaries of their cognate linear transcripts, giving rise to three circRNA subtypes:

(1) canonical (or completely boundary) circRNAs with both BFJs aligning to exon-intron boundaries;

(2) half interior (or half boundary) circRNAs with one, but not both, of the BFJs aligning to exon-intron boundaries;

(3) complete interior (or non-boundary) circRNAs with both junctions appearing inside of exons or introns.

Lariats are byproducts of splicing and can be regarded as variants of canonical circRNAs; for clarity, we list lariats separately here.

Intergenic circRNAs, derived from intergenic regions that often encode poorly annotated noncoding transcripts, can be considered a new distinct subtype of their own.

We collectively refer to complete interior, half interior, and intergenic circRNAs as noncanonical circRNAs (nc-circRNAs) to distinguish them from canonical circRNAs (c-circRNAs).

CircRNA Types Diagram
Position Length Species
intergenic::CCDC127/6:340272-340274-295768-295770-+/- intergenic::CCDC127 protein_coding +/- intergenic 6:340272-295768 44504.0 Crab-eating macaque
intergenic/11:124265052-124265069-124264596-124264613-+/. intergenic Na +/. intergenic 11:124265052-124264596 456.0 Crab-eating macaque
PRKD3/13:70950258-70950264-70950380-70950386--/+ PRKD3 protein_coding -/+ antisense 13:70950264-70950386 122.0 Crab-eating macaque
intergenic/11:124264905-124264913-124264449-124264457-+/. intergenic Na +/. intergenic 11:124264905-124264449 456.0 Crab-eating macaque
intergenic/11:124264914-124264925-124264686-124264697-+/. intergenic Na +/. intergenic 11:124264914-124264686 228.0 Crab-eating macaque
MYL12B/18:63750032-63750040-63730737-63730745-+/+ MYL12B protein_coding +/+ interior 18:63750040-63730745 19295.0 Crab-eating macaque
intergenic/11:124264596-124264613-124265052-124265069--/. intergenic Na -/. intergenic 11:124264596-124265052 456.0 Crab-eating macaque
intergenic/11:124264848-124264868-124263934-124263954-+/. intergenic Na +/. intergenic 11:124264868-124263954 914.0 Crab-eating macaque
DDX19B/20:59913163-59913163-59952375-59952375--/- DDX19B protein_coding -/- interior 20:59913163-59952375 39212.0 Crab-eating macaque
FLYWCH1/20:2858340-2858343-2842351-2842354-+/+ FLYWCH1 protein_coding +/+ interior 20:2858343-2842354 15989.0 Crab-eating macaque