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Tissue: K562
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circRNA ID Gene Gene Type Strand (circRNA/Gene)
circRNA Type i

The back-fusion junctions (BFJs) of circRNAs from genic regions may have three possible positions relative to the nearest exon-intron boundaries of their cognate linear transcripts, giving rise to three circRNA subtypes:

(1) canonical (or completely boundary) circRNAs with both BFJs aligning to exon-intron boundaries;

(2) half interior (or half boundary) circRNAs with one, but not both, of the BFJs aligning to exon-intron boundaries;

(3) complete interior (or non-boundary) circRNAs with both junctions appearing inside of exons or introns.

Lariats are byproducts of splicing and can be regarded as variants of canonical circRNAs; for clarity, we list lariats separately here.

Intergenic circRNAs, derived from intergenic regions that often encode poorly annotated noncoding transcripts, can be considered a new distinct subtype of their own.

We collectively refer to complete interior, half interior, and intergenic circRNAs as noncanonical circRNAs (nc-circRNAs) to distinguish them from canonical circRNAs (c-circRNAs).

CircRNA Types Diagram
Position Length Species
A2ML1/12:8852335-8848718-+/+ A2ML1 protein_coding +/+ canonical (exon-exon) 12:8852335-8848718 3617.0 Human
A2ML1/12:8854249-8852216-+/+ A2ML1 protein_coding +/+ partial 12:8854249-8852216 2033.0 Human
A2ML1/12:8857137-8858276--/+ A2ML1 protein_coding -/+ antisense 12:8857137-8858276 1139.0 Human
A2ML1/12:8861301-8848723-+/+ A2ML1 protein_coding +/+ interior 12:8861301-8848723 12578.0 Human
A2ML1/12:8864009-8860881-+/+ A2ML1 protein_coding +/+ canonical (exon-exon) 12:8864009-8860881 3128.0 Human
A2ML1/12:8869199-8867837-+/+ A2ML1 protein_coding +/+ interior 12:8869199-8867837 1362.0 Human
A2ML1/12:8869204-8867842-+/+ A2ML1 protein_coding +/+ canonical (exon-exon) 12:8869204-8867842 1362.0 Human
A2ML1/12:8874520-8869137-+/+ A2ML1 protein_coding +/+ interior 12:8874520-8869137 5383.0 Human
A2ML1/12:8876244-8876106-+/+ A2ML1 protein_coding +/+ interior 12:8876244-8876106 138.0 Human
A2ML1/12:8876314-8857995-+/+ A2ML1 protein_coding +/+ interior 12:8876314-8857995 18319.0 Human