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Tissue: K562
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circRNA ID Gene Gene Type Strand (circRNA/Gene)
circRNA Type i

The back-fusion junctions (BFJs) of circRNAs from genic regions may have three possible positions relative to the nearest exon-intron boundaries of their cognate linear transcripts, giving rise to three circRNA subtypes:

(1) canonical (or completely boundary) circRNAs with both BFJs aligning to exon-intron boundaries;

(2) half interior (or half boundary) circRNAs with one, but not both, of the BFJs aligning to exon-intron boundaries;

(3) complete interior (or non-boundary) circRNAs with both junctions appearing inside of exons or introns.

Lariats are byproducts of splicing and can be regarded as variants of canonical circRNAs; for clarity, we list lariats separately here.

Intergenic circRNAs, derived from intergenic regions that often encode poorly annotated noncoding transcripts, can be considered a new distinct subtype of their own.

We collectively refer to complete interior, half interior, and intergenic circRNAs as noncanonical circRNAs (nc-circRNAs) to distinguish them from canonical circRNAs (c-circRNAs).

CircRNA Types Diagram
Position Length Species
A2ML1/12:8876378-8876245-+/+ A2ML1 protein_coding +/+ interior 12:8876378-8876245 133.0 Human
A2ML1/12:8876395-8875707-+/+ A2ML1 protein_coding +/+ interior 12:8876395-8875707 688.0 Human
AACS/12:125142636-125142457-+/+ AACS protein_coding +/+ interior 12:125142636-125142457 179.0 Human
AAGAB/15:67231814-67236821--/- AAGAB protein_coding -/- canonical (exon-exon) 15:67231814-67236821 5007.0 Human
AAMP/2:218264239-218264239-218264398-218264398--/- AAMP protein_coding -/- interior 2:218264239-218264398 159.0 Human
AAMP/2:218266181-218266181-218266442-218266442--/- AAMP protein_coding -/- lariat 2:218266181-218266442 261.0 Human
AARS1/16:70252529-70252729--/- AARS1 protein_coding -/- interior 16:70252529-70252729 200.0 Human
AARS1/16:70252715-70252893--/- AARS1 protein_coding -/- interior 16:70252715-70252893 178.0 Human
AARS1/16:70252869-70252876-70252715-70252722-+/- AARS1 protein_coding +/- antisense 16:70252876-70252722 154.0 Human
AARS1/16:70255725-70268377--/- AARS1 protein_coding -/- partial 16:70255725-70268377 12652.0 Human