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Tissue: HT-29
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circRNA ID Gene Gene Type Strand (circRNA/Gene)
circRNA Type i

The back-fusion junctions (BFJs) of circRNAs from genic regions may have three possible positions relative to the nearest exon-intron boundaries of their cognate linear transcripts, giving rise to three circRNA subtypes:

(1) canonical (or completely boundary) circRNAs with both BFJs aligning to exon-intron boundaries;

(2) half interior (or half boundary) circRNAs with one, but not both, of the BFJs aligning to exon-intron boundaries;

(3) complete interior (or non-boundary) circRNAs with both junctions appearing inside of exons or introns.

Lariats are byproducts of splicing and can be regarded as variants of canonical circRNAs; for clarity, we list lariats separately here.

Intergenic circRNAs, derived from intergenic regions that often encode poorly annotated noncoding transcripts, can be considered a new distinct subtype of their own.

We collectively refer to complete interior, half interior, and intergenic circRNAs as noncanonical circRNAs (nc-circRNAs) to distinguish them from canonical circRNAs (c-circRNAs).

CircRNA Types Diagram
Position Length Species
ACTG1/17:81510485-81510490-81510720-81510725--/- ACTG1 protein_coding -/- interior 17:81510485-81510720 235.0 Human
ACTG1/17:81510591-81510595-81510752-81510756--/- ACTG1 protein_coding -/- interior 17:81510591-81510752 161.0 Human
ACTG1/17:81511271-81511271-81511577-81511577--/- ACTG1 protein_coding -/- partial 17:81511271-81511577 306.0 Human
ACTG1/17:81511917-81511925-81512019-81512027--/- ACTG1 protein_coding -/- interior 17:81511917-81512019 102.0 Human
ACTL6A/3:179570202-179570205-179569821-179569824-+/+ ACTL6A protein_coding +/+ partial 3:179570205-179569824 381.0 Human
ACTN1/14:68877085-68877086-68885579-68885580--/- ACTN1 protein_coding -/- interior 14:68877085-68885579 8494.0 Human
ACTN1/14:68979007-68979012-68979236-68979241--/- ACTN1 protein_coding -/- interior 14:68979012-68979241 229.0 Human
ACTN4/19:38702751-38702761-38702489-38702499-+/+ ACTN4 protein_coding +/+ interior 19:38702751-38702489 262.0 Human
ACTN4/19:38703204-38703205-38702964-38702965-+/+ ACTN4 protein_coding +/+ interior 19:38703204-38702964 240.0 Human
ACTN4/19:38704430-38704437-38704304-38704311-+/+ ACTN4 protein_coding +/+ interior 19:38704430-38704304 126.0 Human