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Tissue: A375
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circRNA ID Gene Gene Type Strand (circRNA/Gene)
circRNA Type i

The back-fusion junctions (BFJs) of circRNAs from genic regions may have three possible positions relative to the nearest exon-intron boundaries of their cognate linear transcripts, giving rise to three circRNA subtypes:

(1) canonical (or completely boundary) circRNAs with both BFJs aligning to exon-intron boundaries;

(2) half interior (or half boundary) circRNAs with one, but not both, of the BFJs aligning to exon-intron boundaries;

(3) complete interior (or non-boundary) circRNAs with both junctions appearing inside of exons or introns.

Lariats are byproducts of splicing and can be regarded as variants of canonical circRNAs; for clarity, we list lariats separately here.

Intergenic circRNAs, derived from intergenic regions that often encode poorly annotated noncoding transcripts, can be considered a new distinct subtype of their own.

We collectively refer to complete interior, half interior, and intergenic circRNAs as noncanonical circRNAs (nc-circRNAs) to distinguish them from canonical circRNAs (c-circRNAs).

CircRNA Types Diagram
Position Length Species
ACTG1/17:81511940-81511947-81512069-81512076--/- ACTG1 protein_coding -/- interior 17:81511940-81512069 129.0 Human
ACTG1/17:81512031-81512031-81512288-81512288--/- ACTG1 protein_coding -/- interior 17:81512031-81512288 257.0 Human
ACTG1/17:81512309-81512314-81512412-81512417--/- ACTG1 protein_coding -/- interior 17:81512314-81512417 103.0 Human
ACTN1/14:68874709-68874715-68874870-68874876--/- ACTN1 protein_coding -/- interior 14:68874709-68874870 161.0 Human
ACTN1/14:68880843-68880847-68884243-68884247--/- ACTN1 protein_coding -/- interior 14:68880843-68884243 3400.0 Human
ACTN1/14:68912246-68912247-68921009-68921010--/- ACTN1 protein_coding -/- interior 14:68912246-68921009 8763.0 Human
ACTN4/19:38700993-38700993-38700714-38700714-+/+ ACTN4 protein_coding +/+ lariat 19:38700993-38700714 279.0 Human
ACTN4/19:38701119-38701121-38700597-38700599-+/+ ACTN4 protein_coding +/+ canonical (exon-exon) 19:38701121-38700599 522.0 Human
ACTN4/19:38709650-38709655-38709348-38709353-+/+ ACTN4 protein_coding +/+ interior 19:38709655-38709353 302.0 Human
ACTN4/19:38725695-38725695-38724564-38724564-+/+ ACTN4 protein_coding +/+ lariat 19:38725695-38724564 1131.0 Human